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Although ZofranZuplenz and the generic ondansetron are FDA-approved only for use in treating nausea and vomiting after chemotherapy or radiotherapy or after surgerymany doctors prescribe them for off-label usesincluding treatment of morning sickness in expectant mothers.
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Ondansetron is extensively metabolized in humanswith approximately 5of a radiolabeled dose recovered as the parent compound from the urineThe metabolites are observed in the urineThe primary metabolic pathway is hydroxylation on the indole ring followed by subsequent glucuronide or sulfate conjugation.
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