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Kidney functionKidney disease or reduced kidney function may cause this medication to build up in the bodycausing side effectsIf you have reduced kidney function or kidney diseasediscuss with your doctor how this medication may affect your medical conditionhow your medical condition may affect the dosing and effectiveness of this medicationand whether any special monitoring is needed.
Since other medications may interact with allopurinoltell your doctor about all prescriptionnon-prescriptionillegalrecreationalherbalnutritionalor dietary drugs you are takingespeciallyAzathioprineImuranChlorpropamideDiabineseCyclosporineGengrafSandimmuneNeoralMercaptopurinePurinetholAntibiotics such as ampicillinPrincipenOmnipenothersor amoxicillinAmoxilAugmentinTrimoxWymoxBlood thinners such as warfarinCoumadinDiureticswater pills)
In patients with pre-existing liver diseaseperiodic liver function tests are recommended during the early stages of therapysee WARNINGS
The clearance of oxipurinol is increased by uricosuric drugsand as a consequencethe addition of a uricosuric agent reduces to some degree the inhibition of xanthine oxidase by oxipurinol and increases to some degree the urinary excretion of uric acidIn practicethe net effect of such combined therapy may be useful in some patients in achieving minimum serum uric acid levels provided the total urinary uric acid load does not exceed the competence of the patient’s renal function.
Aluminum saltse.gantacids containing aluminumampicillin amoxicillin angiotensin-converting enzyme inhibitorsACEIscaptoprilramiprilantacidse.galuminum hydroxidecalcium carbonatemagnesium hydroxideazathioprine bendamustine bleomycin carbamazepine chlorpropamide cyclophosphamide cyclosporine didanosine diureticse.gfurosemidehydrochlorthiazidemercaptopurine phenytoin salicylatese.gASAtheophyllinese.gaminophyllineoxtriphyllinetheophyllinewarfarin.
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