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Boceprevir is partly metabolized by CYP3A4/5Co-administration of boceprevir with medicines that induce or inhibit CYP3A4/5 could increase or decrease exposurePlasma trough concentrations of boceprevir were decreased when administered with an NNRTI with a similar metabolic pathway as nevirapineThe clinical outcome of this observed reduction of boceprevir trough concentrations has not been directly assessed.
Viramune is indicated in combination with other anti-retroviral medicinal products for the treatment of HIV-1 infected adultsadolescentsand children of any agesee section 4.2
It is not recommended to co-administer atazanavir/ritonavir and Viramunesee section 4.4
The predetermined primary efficacy comparison was between the Viramune twice daily and the efavirenz treatment groups.
The interaction between nevirapine and the antithrombotic agent warfarin is complexwith the potential for both increases and decreases in coagulation time when used concomitantly.
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